Kevin, here's my issue with airbrushing acrylics. First, I built my first model plastic airplane in 1956, been modeling a long time. Got my first airbrush in the 70's. I own several different airbrushes and use a 3-gal pancake compressor from Harbor freight. My airbrush of choice for model ship building is a Badger 150, medium tip. Use very low air pressure.
I have had no problem with applying acrylic paints with a brush. But, when airbrushing, clogging and cleanup has been an issue. That's not to say I haven't had success, but it's been frustrating and, in my opinion, not worth the effort. Consequently, I will only airbrush using enamel or lacquer-based paints. Acrylic paint seems to clog the inside of the airbrush, not just the nozzle. With solvent based paints, cleanup is easier. Also, I find it is more difficult to get the right consistency and regulate flow with acrylics.
One downside, the color offerings with solvent based paints versus acrylic paints has become limited. Hence, if you buy basic colors and a small color wheel you can match most colors.
The photo below is my current project. Airbrushed the bulwarks a few days ago (enamel paint). My point with the photo is the lack of paint overspray, no spitting or running. I test start with the lowest air pressure and adjust until it's a smooth even flow. When I built the Dory I was going to use Manufacturer recommended acrylic paint but decided to just mix my own batch of enamel.
Again, this is just my experience, lots of trial and error.