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I will put acrylics over an enamel primer coat, but not the other way around. Probably just the styrene junkie in me (shhh! don't tell anyone!)
I would take into account the consequence of the paint failing, even if the probability is low. If the painted area is accessible and resanding and repainting would be relatively easy then it's worth the risk. If not, go carefully and use paints known to be compatible and, to be even more careful, do a test piece. Fair winds!
You may be lucky enough to have an enamel dry over top of an acrylic without orange peel effect, but it will never truly adhere to the surface in my experience.‘Oil will float on water’ is the usual way to remember it.
What make of paint. I thought I was using Humbrol spray ENAMELS until I read the label years later and found they were acrylic! Acrylic is plastic based, so it's the same as spraying a plastic kit. Since acrylic dries and sticks hard to the surface I don't see any problems arising. Though if you can get Humbrol acrylic spray they are quick drying and when fully hardened can be give a light polish with 0000 steel wool. This give perhaps the best finish possible.What will happen if I put rattle can enamel over a thin coat of water base acrylic primer?